The National Institute for Fitness and Sport (NIFS) is dedicated to enhancing human health, physical fitness and athletic performance through research, education and service for people of all ages and abilities. Members of all 14 of IUPUI's teams train at the facility, while working with members of the NIFS training staff.

The 117,000-square foot facility opened in November of 1988. IUPUI athletes train on the 200-meter indoor track, while also utilizing a variety of free weight, Cybex and cardio equipment. IUPUI student-athletes also have access to the regulation full or half size basketball court, the indoor batting nets and pilates studio. 

NIFS also has complete locker rooms, including hot tubs, saunas and shower facilities. NIFS is the former home of the NIKE All-America Basketball Camp, while also hosting NFL Combine workouts, indoor track meets, NBA team workouts and numerous corporate and educational trips. It is also the training facility for members of the Indiana Fever, Indianapolis Indians, Indiana Invaders, Indianapolis Colts and Indianapolis Racing League. 

The building also houses members of the IUPUI Athletics Administration and IU Medical Center. IUPUI teams often utilize the auditorium, classroom and boardroom for team or recruit meetings.